The investigators previous studies of aerobic exercise in women with fibromyalgia (FM) have shown that exercise improves body functions and/or symptom severity in most patients, but not in all. About a third of patients with FM have been shown to have low levels of IGF-1. The purpose of this project is to study individual and biological factors that interact with outcomes of short-term (acute) exercise in FM. Method. A controlled prospective exercise study. Thirty women with FM and 30 healthy age-matched women, aged 20-50 years, will be recruited to the study. Two 15-minute ergometer bicycle exercise tests will be conducted in feasting patients, separated by one month. The first exercise test is at a low and the second at a high intensity. Measurements comprise blood test, pain rating and pain threshold, conducted before and after the test. The levels of IGF-1, IL-6 and IL-8 will be measured, and the changes in them will be related to health status and pain.
Study Type
OBSERVATIONAL
Enrollment
55
Sahlgrenska University Hospital, Dept of Physical Therapy
Gothenburg, Sweden
IGF1 level
Ergometer cycle test of 15 minutes at low respective high intensity. Blood test is done before and after exercise. Change in quantity of IGF1 is measured.
Time frame: 15 min
Pain rating
Pain is rated by the test person before and after the ergometer cycle test.
Time frame: 15 minutes
Pain threshold
Pain threshold is measured before and after the ergometer test.
Time frame: 15 minutes
Interleukin 6 and 8
Blood test is done before and after the ergometer bicycle test. Quantity of interleukin 6 and 8 is measured.
Time frame: 15 minutes
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