Induction of general anesthesia induces frequently arterial hypotension. The short term goal of this study is to evaluate if preemptive volume loading prevents such complication.
This is a randomized, prospective study which will include a total of 200 patients who are scheduled to undergo elective surgery. The research participants will be randomly assigned to * a control group that will receive a low preemptive volume loading (50 mL of gelatin), * a protocol group that will receive a high preemptive volume loading (500 mL of gelatin). Volume loading is preceded by the measurement of stroke volume and cardiac output before and after a passive leg elevation test and followed by a standardized anesthetic protocol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
Enrollment
17
intravenous administration
intravenous administration
Hopital Foch
Suresnes, France
Hypotension
mean arterial pressure less than 70% of the baseline measurement
Time frame: 30 minutes
hemodynamic effect of leg passive elevation test
Time frame: 30 minutes
hemodynamic effect of volume loading
Time frame: 30 minutes
heart rate monitoring
Time frame: 30 minutes
propofol dose when bispectral index is 50
Time frame: 30 minutes
propofol site effect concentration when bispectral index is 50
Time frame: 30 minutes
arterial pressure monitoring
Time frame: 30 minutes
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