Local Metabolic Effects of Ghrelin in Skeletal Muscle and Adipose Tissue

Early Phase 1CompletedNCT01595373

Esben Thyssen Vestergaard10 enrolled

Overview

The metabolic effects of ghrelin is investigated by microdialysis technique. Subjects are healthy young men. End points are interstitial concentrations of glucose, lactate, and glycerol.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

Acyl ghrelinDRUG

Acyl ghrelin 12.5 pg/min infused continuously for 300 minutes

Placebo (Ringer acetate)DRUG

Ringer acetate 2 microliter/min for 300 minutes

Eligibility

Sex: MALEMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy male * age 18-65 years (included) * Body mass index 20-25 (included) Exclusion Criteria: * alcohol abuse * malignant disease * use of any medicine except otc painkillers * any disease recognized * participation in a trial using radioactive isotopes within the last 6 months

Locations (1)

Aarhus University Hospital

Aarhus, Denmark

Outcomes

Primary Outcomes

Interstitial concentrations of glycerol

Time frame: Interstitial concentrations of glycerol at t=120 minutes

Secondary Outcomes

Interstitial concentrations of lactate

Time frame: Interstitial concentrations of lactate at t=120 minutes

Interstitial concentrations of glucose

Time frame: Interstitial concentrations of glucose at t=120 minutes

Data from ClinicalTrials.gov

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