The purpose of this study is to compare heart rate in infants who receive atropine as a part of their medication before intubation to those who do not. To be able to find out , we need to divided babies into 2 groups; group 1 : receives atropine + sedation + muscle relaxant group 2 : receives water or saline ( placebo group) + sedation + muscle relaxant Then we need to compare heart rate during intubation and duration of intubation between the 2 groups.
We hypothesize that premedication for intubation with fentanyl and succinylcholine alone will maintain equal stability of heart rate and oxygen saturation without a prolongation of time to completion of intubation when compared to a protocol using atropine, fentanyl and succinylcholine. In order to answer this question we plan to undertake a prospective randomized double blinded control trial of use of atropine as an adjunct for elective intubation of infants less than 46 weeks postmenstrual age.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
70
Health Sciences Centre
Winnipeg, Manitoba, Canada
RECRUITINGHeart rate less than 80 BPM and oxygen saturation less than 80%
Heart rate and transcutaneous oxygen saturation will be monitored continuously during the procedure and data will be recorded at 3 stages; 1. 2 minutes prior to intubation (after atropine or placebo dose) 2. during intubation 3. 2 minutes after intubation (once ETT secured to face)
Time frame: 5-6 minutes
Heart rate < 100 BPM
Time frame: 5-6 minutes
Oxygen saturation < 85%
Time frame: 5-6 minutes
Duration of intubation attempts
Time frame: 1-2 minutes
Number of intubation attempts
Time frame: 5-6 minutes
Lowest heart rate after premedication
Time frame: 5-6 minutes
Lowest oxygen saturation after premedication
Time frame: 5-6 minutes
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