Bulk Versus Fractionated Stem Cell Infusions in Patients With Hematologic Malignancies Undergoing Stem Cell Transplantation

Inclusion Criteria: * Patients who are considered candidates for an allogeneic stem cell transplantation as treatment for any of the following hematologic disorders: * Acute Leukemia * Myelodysplastic syndrome * Other myeloproliferative disorder (i.e. myelofibrosis, chronic myelomonocytic leukemia, or chronic myelogenous leukemia) * Non Hodgkins Lymphoma * Hodgkins Disease * Multiple Myeloma * Age includes from birth to \< 75 years old. * Patients must have a Karnofsky (adult) or Lansky (pediatric) Performance Status \> 70% * Patients must have adequate organ function measured by: * Cardiac: asymptomatic or if symptomatic then LVEF at rest must be \> 40% * Hepatic: \< 5x ULN ALT and \< 1.5 total serum bilirubin, unless there is congenital benign hyperbilirubinemia. * Renal: serum creatinine \<1.5 mg/dl or if serum creatinine is outside the normal range, then CrCl \> 40 ml/min (measured or calculated/estimated) * Pulmonary: asymptomatic or if symptomatic, DLCO \> 40% of predicted (corrected for hemoglobin). Exclusion Criteria: * Female patients who are pregnant or breast-feeding. * Active viral, bacterial or fungal infection * Patient seropositive for HIV-I/II; HTLV -I/II * Presence of leukemia in the CNS * Candidate for a protocol of higher priority. For the purpose of this study, the following protocols will be considered of higher priority: 10-051 Donor Inclusion Criteria: * HLA compatible related or unrelated donor, (i.e. a fully matched unmanipulated grafts or 1-2 HLA allele disparate donor for CD34 selected grafts). * Meets criteria outlined in the FACT-approved SOP for "DONOR EVALUATION AND SELECTION FOR ALLOGENEIC TRANSPLANTATION" in the Blood and Marrow Transplant Program Manual, document E-1 see http://mskweb5.mskcc.org/intranet/html/80312.cfm * Donor must have adequate peripheral venous catheter access for leukapheresis or must agree to placement of a central catheter. * Wt \>25kg Donor Exclusion Criteria: * Evidence of active infection (including urinary tract infection, or upper respiratory tract Infection) or viral hepatitis exposure (on screening), unless only HBS Ab+ and HBV DNA negative. * Medical or physical reason which makes the donor unlikely to tolerate or cooperate with growth factor therapy and leukapheresis. * Factors which place the donor at increased risk for complications from leukapheresis or GCSF therapy (e.g., autoimmune disease, sickle cell trait, symptomatic coronary artery disease requiring therapy). * Pregnancy (positive serum or urine β-HCG) or breastfeeding. Women of childbearing age must avoid becoming pregnant while on the study