The cerebrovascular autoregulation (AR) is impaired in patients with hepatic encephalopathy. Patients with the indication to liver transplantation mostly have mild to severe hepatic encephalopathy. Transplantation should recover the encephalopathy. The aim of the study is to investigate the AR during liver transplantation, with the questions if the AR is impaired at the beginning of surgery and if there are changes in AR. For follow up the AR will be measured at the first days after transplantation at the ICU.
The cerebrovascular autoregulation (AR) will be measured using transcranial doppler and calculating the index of autoregulation Mx. This measurement is continuous with online calculation. So, the possible changes over the whole time of surgery can be detected. Furthermore, the measurement of AR at the ICU will be performed daily at the same time over a measurement period of 60 Minutes and the time course of AR after liver transplantation will be described.
Study Type
OBSERVATIONAL
Enrollment
20
No intervention is planned in this study
University Medical Center
Mainz, Germany
RECRUITINGChanges of cerebrovascular autoregulation during liver transplantation
Measuring cerebrovascular autoregulation during the whole liver transplantation and compare the index of AR at the beginning with index of AR Mx after reperfusion of the transplantated liver
Time frame: During the surgery
Time course of cerebrovascular autoregulation after liver transplantation
Meaurement of cerebrovascular autoregulation daily for the first 4 days and calculating a time course
Time frame: First 4 days after transplantation
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