Treatment of Abdominal Abscesses With or Without Fibrinolysis

Children's Mercy Hospital Kansas City92 enrolled

Overview

The objective of this study is to evaluate the utility of fibrinolysis when draining an abdominal abscess as defined by length of stay after drainage.

The hypothesis is that fibrinolysis of a abscess will shorten hospital stay compared to drainage alone.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Abdominal Abscess Tissue Plasminogen Activator

Interventions

Tissue plasminogen activator abscess flushPROCEDURE

Thirteen ml of 10% tPA in saline at time of drain and twice daily thereafter.

Saline flush of abscessPROCEDURE

Thirteen ml of saline is used to flush abscess at time of drain placement and twice daily thereafter.

Eligibility

Sex: ALLMax age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients under age 18 found to have an abscess in their abdomen related to perforated appendicitis that requires a drain either prior to or after appendectomy. Exclusion Criteria: * Patients with known immune deficiency per medical record review * Patients with another condition affecting surgical decision making or recovery * Patients with drain unable to be placed

Locations (1)

Children's Mercy Hospital

Kansas City, Missouri, United States

Outcomes

Primary Outcomes

Length of hospital stay

Length of time required for meeting discharge criteria

Time frame: 1-2 weeks

Data from ClinicalTrials.gov

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