The aim of this study is to assess the ability of clonidine to reduce the mean pulmonary artery pressure in patients with pulmonary hypertension subjected to cardiac surgery.
Prospective, clinical-interventionist, randomized, and double-blind study. Patients with group 2 pulmonary hypertension will be included and subjected to cardiac surgery with extracorporeal circulation. Mean pulmonary artery pressure and the doses of dobutamine and sodium nitroprusside will be assessed four times: before (T0) administration of 2 μg/kg of intravenous clonidine or a placebo, 30 minutes after the onset of treatment (T1), immediately after extracorporeal circulation (T2), and 10 minutes after the injection of protamine (T3).
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
29
Luiz Fernando dos Reis Falcao
São Paulo, São Paulo, Brazil
Reduction pulmonary artery pressure
Assessed four times: before (T0) administration of 2 μg·kg-1 of intravenous clonidine or a placebo, 30 minutes after the onset of treatment (T1), immediately after ECC (T2), and 10 minutes after the injection of protamine (T3).
Time frame: During intraoperative (hours)
Doses of Dobutamine
Evaluate the need for using and dose of dobutamine immediately after extracorporeal circulation between groups.
Time frame: During intraoperative (hours)
Doses of Sodium nitroprusside
Evaluate the need for using and dose of sodium nitroprusside immediately after extracorporeal circulation between groups.
Time frame: During intraoperative (hours)
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