The purpose of this study is to determine the effect that telaprevir and boceprevir has on the pharmacokinetics of maraviroc.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
14
Maraviroc 150 mg BID x 5 days with food
Maraviroc 150 mg BID + Boceprevir 800 mg TID x 10 days with food
Maraviroc 150 mg BID + Telaprevir 800 mg TID x 10 days with food
Pfizer Investigational Site
Brussels, Belgium
Maraviroc plasma pharmacokinetic parameters: AUC12, Cmax, and C12h on Period 1, Day 5 and Periods 2 and 3, Day 10
Time frame: 25 days
Maraviroc plasma pharmacokinetic parameters: Tmax on Period 1, Day 5 and Periods 2 and 3, Day 10
Time frame: 25 days
Boceprevir plasma pharmacokinetic parameters: AUC8, Cmax, C8h, and Tmax on Period 2, Day 10
Time frame: 10 days
Telaprevir plasma pharmacokinetic parameters: AUC8, Cmax, C8h, and Tmax on Period 3, Day 10
Time frame: 10 days
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