Evaluation of Extended Intravenous of Beta-lactams in the Treatment of Serious Gram-negative Infections in Critically Ill Patients

National Taiwan University Hospital100 enrolled

Overview

The purpose of this study is to evaluate the PK/PD parameters, safety and efficacy of extended infusion of beta-lactams in intensive care patients who are infected with Gram-negative bacteremia or pneumonia at National Taiwan University Hospital (NTUH).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

100

Conditions

Gram-Negative Bacterial Infections

Interventions

Beta-LactamsDRUG

infusion time: 30 mins or 1 hr

Beta-LactamsDRUG

infusion time 4 hrs

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients (\> 18 years) * Admitted on the intensive care unit * Starting a treatment with beta-lactams antibiotics * Signed informed consent * Expected to live \> 3 days Exclusion Criteria: * renal insufficiency (estimated clearance \< 20 ML /MIN) * renal replacement therapy * ANC \< 1000 103 µl * pregnancy * drug abuse

Locations (1)

NTUH

Taipei, Taiwan

RECRUITING

Outcomes

Primary Outcomes

serum concentrations of beta-lactams

Determination of serum concentrations of beta-lactams

Time frame: 6 hours

Central Contacts

Shu-Wen Lin, Pharm D.

CONTACT

(02)2312-3456 shuwenlin@ntu.edu.tw

Data from ClinicalTrials.gov

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