Establish a Vegetable Signature Database From Human Metabolomics Responses

National Health Research Institutes, Taiwan50 enrolled

Overview

Vegetable is well known to prevent chronic disease,however, the mechanism of its nutrients and non-nutrients still remains to be discovered.We design a feeding study which provides plant foods to subjects one by another and monitoring metabolomic changes up to 7 hours.The goal of this study is to establish a protocol for documenting metabolomics response to plant foods and try to characterize plant foods in terms of their anti-hypertension potentials with metabolomic profiling information.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Human Metabolomic Responses to Plant Foods Blood Pressure

Interventions

Low phytochemical diet(LPD), high phytochemical diet(HPD)OTHER

LPD is a basal diet which low in soy,vegetable and fruit and other plant food to approach low phytochemical. HPD is the diet which add two serving test vegetable in the lunch of LPD.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 60 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age :18-60 years * Body Mass Index :18.5-30(kg/m2) * Non-smoking,alcohol abusing,and other bad hobbies Exclusion Criteria: * With regular drug intake e.g. anti-hypertensive or antidiabetes drug or history of immune, hepatic and metabolic disease or other unsuitable disorders e.g. cancer. * unwilling to stop regular food supplement e.g. vitamins, herb * cannot cooperate with designed diet * History of urinary tract infection or antibiotic use within the previous 3 month

Locations (1)

National Health Research institues, Taiwan

Miaoli County, Taiwan

Outcomes

Primary Outcomes

blood pressure

fasting, before lunch,and every 1 hr after lunch

Time frame: one day

Secondary Outcomes

metabolomic profile of serum and urine

serum sample will be measure fasting ,before lunch,and every 1 hr after lunch;urine sample will be measure fasting ,before lunch(0hr),0-2 hr,2-4hr 4-7hr after lunch

Time frame: one day

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.