Local Assessment of Ventilatory Management During General Anesthesia for Surgery

European Society of Anaesthesiology10,690 enrolled

Overview

Objectives 1. To characterize mechanical ventilation practices during general anesthesia for surgery 2. To assess the dependence of intra-operative and post-operative pulmonary complications on intra-operative Mechanical Ventilation (MV) settings

Research questions * What MV-settings are used during general anesthesia for surgery? * Do MV-settings vary in and/or between centers? * Do MV-settings vary internationally? * Are MV-settings associated with incidence of intra-operative pulmonary complications? * Are MV-settings associated with incidence of post-operative pulmonary complications?

Study Type

OBSERVATIONAL

Enrollment

10,690

Conditions

Surgery Anaesthesia Ventilator-Induced Lung Injury Lung Injury Pneumonia Pneumothorax Respiratory Distress Syndrome, Adult

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age ≥ 18 years * All surgical procedures requiring invasive mechanical ventilation (MV)during general anesthesia for laparoscopic or non-laparoscopic surgery. * This includes MV performed with supra-glottic devices (e.g. laryngeal mask) * This includes patients receiving MV at the onset of the procedure (e.g. Intensive Care Unit patients) * This includes patients who will receive one-lung ventilation during the procedure Exclusion Criteria: * Obstetric surgical procedures or any procedure during pregnancy * Surgical procedures outside the operating room * Surgical procedures involving extra-corporal circulation

Locations (19)

University of Colorado School of Medicine/University of Colorado Hospital

Aurora, Colorado, United States

Massachusetts General Hospital

Boston, Massachusetts, United States

Mayo Clinic

Rochester, Minnesota, United States

North Estonia Medical Center

Tallinn, Estonia

Tartu University Hospital

Tartu, Estonia

University Hospital Carl Gustav Carus, Dresden University of Technonology, Department of Anesthesiology and Intensive Care Therapy

Dresden, Germany

Duesseldorf University Hospital

Düsseldorf, Germany

Diakoniekrankenhaus Friederikenstift

Hanover, Germany

Ospedale San Martino, Dipartimento di scienze chirurgiche e diagnostiche integrate

Genoa, Italy

Ospedale San Raffaele

Milan, Italy

...and 9 more locations

Outcomes

Primary Outcomes

Post-operative pulmonary complications, possibly related to ventilation strategy

Effect of Mechanical Ventilation settings during general anesthesia for surgery on the incidence of post-operative pulmonary complications (new or prolonged invasive or non-invasive mechanical ventilation, need for oxygen therapy, respiratory failure, pneumonia, ARDS 'Acute Respiratory Distress Syndrome', pneumothorax) Defined post-operative pulmonary complications are recorded from the medical chart on day 0, 1, 2, 3, 4 and 5 after surgery. On day 28 length of hospital stay and in hospital death are assessed.

Time frame: Post-operative on day of surgery, day 1, 2,3,4,5 and day 28

Secondary Outcomes

Intra-operative complications related to the ventilation strategy

Time frame: Time point(s) at which outcome measure is assessed is is: Day of surgery, day 1, 2, 3, 4, 5 and 28 after surgery

Mechanical ventilation-settings during general anesthesia for surgery

* Variation of applied MV settings within centers * Variation of applied MV settings between centers on an international basis

Time frame: During the surgical procedure, from moment of to tracheal extubation or discharge from operation room (in case patient remains on mechanical ventilation)