Safety and Efficacy Study of BMS-823778 to Treat Uncontrolled High Blood Pressure in Overweight and Obese Patients

Inclusion Criteria: * Qualifying seated blood pressure between ≥90 and ≤105 mmHg diastolic AND ≤155 mmHg systolic * Mean 24-hour diastolic blood pressure ≥85 mmHg * Body mass index (BMI) ≥27 kg/m2 * If receiving an oral anti-hyperglycemic medication or a cholesterol lowering medication, receiving a stable dose for at least 6 weeks Exclusion Criteria: * History of Cushing's disease or syndrome, or Addison's disease * Glycosylated hemoglobin (HbA1c) ≥10% * Cerebrovascular insult, unstable angina, or myocardial infarction (MI) within 6 months * History of impaired renal or hepatic function * BMI ≥50 kg/m2 * Any injectable antihyperglycemic agent (such as insulin) within 16 weeks * Currently receiving more than one class of antihypertensive agents within 4 weeks * Daily use of nonsteroidal anti-inflammatory agents within 1 week * Use of androgen medications, including topical preparations, within 6 weeks * Diagnosis or history of breast cancer