Comparison of Morphine and Fentanyl/Midazolam in Intensive Care Unit

Clínica de Los Andes IPS90 enrolled

Overview

Hypothesis: Morphine infusion decreases time to mechanical ventilation weaning and extubation, as compared to the combination of fentanyl and midazolam in critically-ill patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

SINGLE

Enrollment

Conditions

Respiratory Failure

Interventions

Morphine infusionDRUG

Conventional dose

Fentanyl and Midazolam infusionDRUG

Conventional dose

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adults admitted to ICU requiring mechanical ventilation Informed consent Exclusion Criteria: * Less than 18 years old * Consent denial

Locations (1)

Clinica de los Andes IPS

Tunja, Departamento de Boyacá, Colombia

Outcomes

Primary Outcomes

Time from sedation discontinuation to first T-Tube time from sedation

Time frame: 12-120 hours

Secondary Outcomes

Time from sedation discontinuation to extubation time from sedation

Time frame: 12-180 hours

Data from ClinicalTrials.gov

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