Comparison of Pulse Hemoglobin and Pleth Variability Index

Loma Linda University299 enrolled

Overview

The purpose of this study is to investigate whether a validated sensor that is able to measure how much oxygen-carrying molecules called hemoglobin using pulse hemoglobin and Pleth Variability Index (PVI)\] are in your blood during surgery can help your doctors manage how much fluid and possibly blood you need to get during your surgery. The hope of the study is that the device may provide an early indication you are having bleeding and this may mean you need to be treated with a transfusion. Our current method of checking this is by getting a blood sample for analysis. The investigators hope is that this device may be able to alert the clinician of the need for blood or fluids without a blood draw being needed.

Study Type

OBSERVATIONAL

Enrollment

299

Conditions

Anemia Fluid Management

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subjects must be \>18 years old; * must be having a major surgical procedure; * The pre-operative estimation of blood loss must be at least 15% of the total blood volume Exclusion Criteria: * Does subject have hemoglobinopathy; * cardiac arrhythmias producing irregular rhythms; * severe pulmonary disease; * procedures where loss of more that 10 to 15% of total blood volume is unlikely; * subject refusal

Locations (1)

Outcomes

Primary Outcomes

The difference between hemoglobin values from the two monitors.

The primary outcome measure is the difference between hemoglobin values from the pulse oximetry device and from the arterial blood gas co-oximeter.

Time frame: Pulse hemoglobin will be monitored during the surgery from the first arterial blood gas drawn to the last ABG drawn.

Secondary Outcomes

Difference between measures compared to patient characteristics

Secondary outcome measures are the size of difference between measures compared to patient characteristics.

Time frame: Start of surgery to end of surgery