The purpose of this study is to assess the pharmacodynamic effect of ticagrelor in ACS patients undergoing an Ad Hoc PCI
A randomized, open-label, multiple-center, parallel group study to compare the platelet inhibition with VerifyNow assay of ticagrelor versus clopidogrel in troponin negative Acute Coronary Syndrome (ACS) subjects undergoing Ad Hoc percutaneous coronary intervention (PCI)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
343
180 mg loading dose
600 mg loading dose
Research Site
Birmingham, Alabama, United States
Research Site
San Francisco, California, United States
Research Site
Washington D.C., District of Columbia, United States
Inhibition of the P2Y12 Receptor at 2 Hours After Loading Doses of Ticagrelor and Clopidogrel as Measured by P2Y12 Reaction Units (PRU) From VerifyNow™
Participants with low (\<150) baseline PRU values were excluded.
Time frame: 2 hours after the loading dose
Inhibition of the P2Y12 Receptor at 0.5 Hours, End of PCI, and 8 Hours After Loading Doses of Ticagrelor and Clopidogrel as Measured by PRU From VerifyNow™
Participants with low (\<150) baseline PRU values were excluded.
Time frame: 0.5 hours, end of PCI, and 8 hours after the loading dose
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Research Site
Jacksonville, Florida, United States
Research Site
Ypsilanti, Michigan, United States
Research Site
Minneapolis, Minnesota, United States
Research Site
Tupelo, Mississippi, United States
Research Site
North Kansas City, Missouri, United States
Research Site
Belleville, New Jersey, United States
Research Site
New York, New York, United States
...and 6 more locations