High-protein High-fiber Diet in Patients With Primary Biliary Cirrhosis

Inclusion Criteria: * Controls Diagnose of primary biliary cirrhosis: * Biochemical evidence of cholestasis: based mainly on alkaline phosphatase elevation * Presence of antimitochondrial antibodies (AMA) * Histologic evidence of nonsuppurative destructive cholangitis and destruction of interlobular bile ducts. Ambulatory patients * Cases Diagnose of primary biliary cirrhosis: * Biochemical evidence of cholestasis: based mainly on alkaline phosphatase elevation * Presence of antimitochondrial antibodies (AMA) * Histologic evidence of nonsuppurative destructive cholangitis and destruction of interlobular bile ducts. Diagnose of liver cirrhosis by two or more of the following criteria: * Albumin \< 3.4 g/dL * INR ≥ 1.3 * Total bilirubin ≥ 2 mg/dL * Portal hypertension (esophageal varices, splenomegaly, ascites, etc.) * Liver biopsy Ambulatory patients Exclusion Criteria: * Overlapping syndrome with predominant autoimmune hepatitis * Hospitalized patients * Acute or chronic renal failure * Hepatocellular carcinoma * Pregnancy * Neuropsychiatric disorders (Schizophrenia, bipolar disorder, dementia and attention-deficit hyperactivity disorder)