Effect of KB003 in Subjects With Asthma Inadequately Controlled by Corticosteroids

Key Inclusion Criteria: * A diagnosis of asthma established for at least 2 years * Symptomatic asthma as defined by the Juniper Asthma Control Questionnaire * Symptomatic asthma despite stable treatment with inhaled corticosteroids fluticasone or budesonide, or other corticosteroids, for at least 12 weeks * Currently receiving inhaled long-acting beta agonist (LABA) or previously documented LABA intolerability or lack of responsiveness * At least 2 exacerbations (no more than 6) in the previous 12 months that required systemic corticosteroids or at least a doubling of daily oral dose Key Exclusion Criteria: * Acute asthma worsening (requiring emergency room visit, hospitalization, urgent care, physician visit, or change in asthma medications) or lower respiratory tract infection requiring the use of antibiotics, within 4 weeks prior to Screening Visit. * History of life-threatening asthma with admission to the intensive care unit requiring the use of mechanical ventilation within the past 12 months * Use of any immunosuppressive or immunomodulatory agents within 12 weeks or an investigational agent within 4 weeks prior to Screening Visit * History of any cardiovascular, neurological, hepatic, or renal condition * History of smoking within the past 12 months