A Phase 1 Dose Escalation Study of AV-203, an ERBB3 Inhibitory Antibody, in Subjects With Advanced Solid Tumors

Inclusion Criteria: * ≥ 18 years of age * Histologically and/or cytologically confirmed primary diagnosis * Metastatic or advanced solid tumor, that has recurred or progressed following standard therapies, or for which no standard therapy exists * Must have available tumor tissue or be willing to undergo biopsy prior to enrollment * Eastern Cooperative Oncology Group (ECOG) Performance status of 0 or 1 * Blood Chemistry and Hematology results within defined limits Exclusion Criteria: * History of severe allergic or anaphylactic reactions or hypersensitivity to recombinant proteins or excipients in the investigational agent * Current central nervous system (CNS) or leptomeningeal metastases, or history of CNS or leptomeningeal metastases. * Significant conduction disturbance, history of a severe arrhythmia, or history of a familial arrhythmia * Significant cardiovascular disease * Significant thromboembolic or vascular disorders within prior 3 months * Any other medical condition or psychiatric condition that, in the opinion of the Investigator, might interfere with the subject's participation in the trial or interfere with the interpretation of trial results * Known history of positive results for hepatitis C, hepatitis B, or human immunodeficiency virus. * For female subjects, pregnancy or lactation.