Membrane Shedding During Septic Shock

University Hospital, Strasbourg, France100 enrolled

Overview

Microparticles (MPs) result from plasma cell membrane remodeling and shedding after cell stimulation or apoptosis. MPs are know recognized as a pool of bioactive messengers with emerging role in pathophysiology of immune and cardiovascular diseases. MPs have been characterized during septic shock and may contribute to dissemination of pro-inflammatory and procoagulant mediators. This is a prospective observational study of circulating MPs and blood coagulation in 100 septic shock patients admitted in 3 tertiary hospitals medical ICU at baseline (D1), D2, D3, D4 and D7.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Septic Shock

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Septic shock * Informed consent Exclusion Criteria: * Class IV heart failure * Child-Plugh grade C cirrhosis * Cancer under active treatment * BMI\>35 kg/m² * Moribund patient * DNR decision

Locations (3)

Service Réanimation Médicale et Médecine Hyperbare, CHU

Angers, France

Centre Hospitalier

Mulhouse, France

Service de Réanimation Médicale, Nouvel Hôpital Civil, Hôpitaux Universitaires

Strasbourg, France

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.