Role of Activin A (ActA) in the Human Cancer Cachexia

Inclusion Criteria: * 18-year-old or older * Colorectal or lung cancer demonstrated by histology or cytology * New diagnosis or new recurrence * Expected survival more than 3 months * No previous history of other cancer in the last 5 years * No pregnancy or lactation * Signed informed consent Exclusion Criteria: * Non-caucasian * Major digestive malabsorption * Major depression * Artificial nutrition * Height doses of steroids (\>1 mg/kg hydrocortisone equivalent) * Hyperthyroidism * Other causes of malnutrition * Expected survival less than 3 months * Severely impaired walking * Anticoagulants or antiplatelet therapy * Disability or medical condition which might prevent the compliance to the protocol * Any conditions which may prevent the compliance to the protocol * Performance status ECOG \> ou = 4 * Participation to other clinical studies