The CAPTAIN Trial: Cerebrolysin Asian Pacific Trial in Acute Brain Injury and Neurorecovery

Inclusion Criteria: * Clinical diagnosis of TBI and a GCS 7-12 * Only isolated TBI * CT * Pre-Trauma Karnofsky-Index = 100 * Age 18-60 years * Male and female patients * Time to needle for study medication within 6 hours after injury * Patient is not pregnant or lactating during the trial and is not of childbearing potential * Patient was able to speak, read and write in a pre-defined study language before the accident. * Reasonable expectation of completion of outcome measures at follow-up * Written informed consent Exclusion Criteria: * Evidence of pre-existing major health problems * Any neurological or non-neurological condition independent from TBI that might influence the functional outcome or other efficacy outcome measures * Injury of writing hand influencing cognitive or other outcome measures * Clear clinical signs of intoxication influencing the evaluation * Major drug dependency including alcohol * Chronic treatment with steroids, Ca2+-channel blockers or major anticoagulants * Penetrating high-velocity missile head trauma * Stab wound trauma into the brain * Patients with spinal cord injury