The investigators perform a retrospective microarray gene expression profiling study of FFPE from a cohort of DLBCL patients with whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay. The investigators also study the pattern of microRNA from patients with diffuse large B-cell lymphoma. The results of gene expression profiles and microRNA is correlated with clinical outcomes of diffuse large B-cell lymphoma.
1. Whole genome cDNA mediated Annealing Selection and Ligation (WG-DASL) assay * Diffuse large B-cell lymphoma patients * Paraffin-embedded tissue * End points: Progression-free survival, overall survival * Statistics: Leave one-out method 2. Nano string assay for microRNA * Diffuse large B-cell lymphoma patients * Paraffin-embedded tissue * End points: Progression-free survival, overall survival * Statistics: Leave one-out method
Study Type
OBSERVATIONAL
Enrollment
350
Samsung Cancer Research Institute
Seoul, South Korea
Number of patients who relapse or progress after 1st line chemotherapy
Time frame: two years
Number and type of genes and microRNA which are significantly related with relapse or progression (P < 0.05)
Time frame: two years
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