The purpose of this study is to determine if Vortioxetine 20 mg/day will lead to changes in neural activity (BOLD signal), as measured using fMRI, in brain areas associated with executive functioning and memory during cognitive task performances compared to placebo in subjects remitted from depression and in controls, and to explore if Vortioxetine will lead to improved cognitive performance in the absence of depression.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
96
encapsulated 20 mg tablets, orally, once daily for 13 to 14 days
capsules, orally, once daily for 13 to 14 days
GB001
Headington, United Kingdom
Effect of Vortioxetine on BOLD signal in fMRI of the brain areas associated with executive function (working memory)
Time frame: Day 1 to Day 13
Effect of Vortioxetine on BOLD signal in fMRI of the brain areas associated with spatial memory
Time frame: Day 1 to Day 13
Effect of Vortioxetine on cognitive performance (executive function, memory, speed of processing, attention, cognitive flexibility) and emotional processing
Time frame: Day 1 to Day 13
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