Locating Regions of Interest in Generalized Anxiety Disorder Using Function Magnetic Resonance Imaging (fMRI)

Generalized Anxiety Disorder(GAD)Group: Inclusion Criteria: * Clinical diagnosis of Generalized Anxiety Disorder * Hamilton Anxiety Rating Scale score of 18 or higher * Hamilton Rating Scale for Depression score of 17 or less * Fluency in English * Capacity to understand the nature of the study and willingness to sign informed consent for Exclusion Criteria: * History of epilepsy or head trauma (Loss of consciousness\>5 minutes) with the past 6 months * Lifetime history of increased intracranial pressure, seizure disorder, stroke, brain tumor, multiple sclerosis or brain surgery * A review of patient medications by the study physician indicates an increased risk of seizure * An active autoimmune, endocrine, viral, or vascular disorder affecting the brain; any unstable cardiac disease; hypertension; or severe renal or liver insufficiency * Substance use disorder or posttraumatic stress disorder (PTSD) within the past 6 months * Lifetime bipolar disorder, obsessive-compulsive disorder (OCD), psychotic disorder, mental retardation, or pervasive development disorder * Any psychotic features, including dementia or delirium * Medication change within past 3 months * Current serious suicidal or homicidal ideation, and/or serious suicidal attempt within past 6 months * Serious, unstable, or terminal medical condition or clinically judged too psychiatrically unstable to participate in the study * Any contraindication for participation in MRI scan Nonclinical Control Group: Inclusion Criteria: * Absence of any psychiatric diagnosis Exclusion Criteria: * History of epilepsy or head trauma (Loss of Consciousness\>5 minutes) with the past 6 months * Lifetime history of increased intracranial pressure, seizure disorder, stroke, brain tumor, multiple sclerosis or brain surgery * A review of patient medications by the study physician indicates an increased risk of seizure * An active autoimmune, endocrine, viral, or vascular disorder affecting the brain; any unstable cardiac disease; hypertension; or severe renal or liver insufficiency * Substance use disorder or PTSD within the past 6 months * Lifetime bipolar disorder, OCD, psychotic disorder, mental retardation, or pervasive development disorder * Any psychotic features, including dementia or delirium * Medication change within past 3 months * Current serious suicidal or homicidal ideation, and/or serious suicidal attempt within past 6 months * Serious, unstable, or terminal medical condition or clinically judged too psychiatrically unstable to participate in the study * Any contraindication for participation in MRI scan