Doppler Evaluation in RA Patients After Adalimumab.

Inclusion Criteria: * Adult patient (\> 18 years of age), male or female * Rheumatoid arthritis according to the 1987 ACR or 2010 EULAR/ACR classification criteria * Moderate to high disease activity * Ongoing anti-rheumatic treatment with DMARD, with stable dosage during the last 3 months, and being a candidate for anti-TNF add-on therapy OR ongoing treatment with first anti-TNF therapy and being a candidate for switch to another anti-TNF therapy * Women with child-bearing potential: use of an adequate method of contraception to avoid pregnancy throughout the study * Signed Informed Consent \*Signed Informed Consent must be obtained before any study specific procedures take place. Exclusion Criteria: * Biologic treatment with Adalimumab before inclusion * Two or more ongoing biologic treatments before inclusion * Treatment with other biologic treatment than anti-TNF therapy before inclusion * Any contraindication for treatment with Adalimumab * Intraarticular corticosteroid injection during the last 4 weeks before each follow-up visit * Positive for tuberculosis or hepatitis B. * Ongoing pregnancy or lactation