Preoperative Vitamin D for Post-thyroidectomy Hypocalcemia

University of Alberta

Overview

The purpose of this study is to determine if pre-operative vitamin D supplementation lowers the incidence of post-operative transient or permanent hypoparathyroidism in patients undergoing total thyroidectomy.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Conditions

Hypocalcemia

Interventions

Vitamin DDRUG

Vitamin D 800 units for 4 weeks preoperatively

PlaceboDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Patients undergoing total thyroidecomty +/- CND * Adult (age \> or = 18) Exclusion Criteria: * Known chronic kidney disease * Known primary hyper or hypoparathyroidism * Known hypoalbuminemia * Concurrent use medications affecting calcium metabolism * Completion hemithyroidectomy

Locations (1)

University of Alberta

Edmonton, Alberta, Canada

Outcomes

Primary Outcomes

Hypocalcemia

Clinical signs and symptoms(paraesthesias, etc.) OR Laboratory evidence (ICa \< 0.9) Need for IV calcium supplementation

Time frame: Transient (<72 hrs post-operatively)

Secondary Outcomes

Hypocalcemia

ICa at 6 weeks and need for continued supplementation beyond 6 weeks post-op (i.e. 3 months follow-up post-operatively)

Time frame: Permanent (>4 weeks)

Data from ClinicalTrials.gov

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