The purpose of this study is to determine whether glucose-fructose intake during training increases lactate transport and oxidation and improve endurance performance.
The study will enroll 24 healthy male volunteers. After baseline assessment of lactate transport and endurance performance, subjects will be randomized to either a 3-week intervention arm in which they will train with glucose-fructose intake during training, or to a control arm (water during training). After this 3-week intervention, lactate transport and endurance performance will be assessed again.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
17
0.8 g/h glucose and 0.5 g/h fructose during training
Only water intake during training
University of Lausanne
Lausanne, Canton of Vaud, Switzerland
Change in lactate transport
Measurement of lactate production, utilization, oxidation and clearance during a 90 min cycling exercise at 50% VO2 max (measured with 13C-lactate)
Time frame: At baseline (before training) and after the 3-week training protocol
Change in muscle monocarboxylate transporters (MCTs) expression and protein content
MCTs expression (mRNA) and protein content after muscle biopsy
Time frame: At baseline (before training) and after the 3-week training protocol
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