Phase 3 Study to Evaluate the Efficacy and Safety of Droxidopa on Orthostatic Hypotension Treatment in Hemodialysis Patients

Inclusion Criteria: 1. Female or male aged great than 20 years of age 2. Patient with at least 3 month documented requirement of regular hemodialysis session 3. Patient with a decrease of 20 mmHg in SBP or 10 mmHg in DBP within 5 minutes of standing after the end of hemodialysis in at least 2 of 3 sessions during the screening period. 4. Subject with subjective complain of light headedness related to the orthostatic hypotension AND with a VAS score 4 in at least 2 of 3 sessions during the screening period. 5. Willing and able to comply with the study procedure and sign a written informed consent Exclusion Criteria: 1. Female who is pregnant, lactating or planning to be pregnant within 3 months, or female of childbearing potential who is not using medically recognized method of contraception 2. Subject with closed angle glaucoma 3. Subject with severe hypertension 4. Subject with liver disorder 5. Subject with Hct great than 36% 6. Subject with confusion, hallucination, or delusion 7. Subject with severe disease which may limit survival during the study period, or confound the results of the study as judged by the investigator, such as hyperthyroidism, artery stenosis, severe lung disorders, severe asthma, chronic open angle glaucoma, uncontrolled diabetic gangrene 8. Subject who takes any anti-hypotensive drugs within 7 days prior to randomization, such as midodrine, etilefrine or amezinium 9. Subject who takes ephedrine, pseudoephedrine within 7 days prior to randomization 10. Subject who use of any investigational product within 4 weeks prior to randomization 11. Subject who requires blood transfusions within 3 months before screening, and are not suitable to participate the trial as judged by the investigator 12. Histories of hypersensitive to droxidopa 13. Histories of peripheral vascular disease, coronary artery disease and are not suitable to participate the trial as judged by the investigator 14. Histories of hemorrhage complication within 3 months before the screening visit, such as GI bleeding, intracranial bleeding or traumatic hemorrhage, and are not suitable to participate the trial as judged by the investigator 15. In investigator's opinion, subjects who are unlikely to adequately cooperate and follow the procedures