Endostar Combination With Chemotherapy for the Metastatic Nasopharyngeal Carcinoma

Inclusion Criteria: * Diagnosed metastatic NPC patient who have received radiotherapy or chemoradiotherapy with an at least 6 months interval * Have measurable lesions * No dysfunction of the major organs * Can understand this study and give a signed informed consent certificates * without a history of allergic reaction to the biological agents Exclusion Criteria: * Pregnant or lactating women; Women of child-bearing age without contraception * with a Serious infection or dysfunction of the major organs * have taken other antitumor drugs during the period of 30 days ahead of this clinical trial * allergic to the Escherichia coli preparations * Cann't understand this study and give a signed informed consent certificates