Causes of Visual Loss in Retinal Disease

Royal Surrey County Hospital NHS Foundation Trust2,000 enrolled

Overview

This is a study of visual outcomes in retinal disease that seeks to identify the causes of visual loss. This data will be used to predict which patients are at risk of losing vision and how they can be better treated.

This is a study of visual outcomes in retinal disease. It is an observational study of patients who have been seen in the retinal clinic, and involves a retrospective casenotes analysis to identify patients who have suffered visual loss and the reason for that visual loss. These data will be analysed to enable the identification of factors that predict visual loss in patients who present earlier in the course of their disease.

Study Type

OBSERVATIONAL

Enrollment

2,000

Conditions

Uveitis Scleritis

Interventions

Immunosuppressive AgentsDRUG

Treatment with systemic corticosteroids and/or immunosuppressive agents Treatment with local corticosteroids and other drugs

Eligibility

Sex: ALLMin age: 16 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients with a diagnosis of ocular inflammation * patients with at least 6 months of follow-up Exclusion Criteria: * patients without a diagnosis of ocular inflammation * patients with less than 6 months of follow-up

Locations (2)

Moorfields Eye Hospital

London, London, United Kingdom

Royal Surrey County Hospital

Guildford, UK, United Kingdom

Outcomes

Primary Outcomes

Visual acuity at 5 years

Best-corrected visual acuity at 5 years

Time frame: 5 years

Secondary Outcomes

Visual acuity at 10 years

Best corrected visual acuity at 10 years

Time frame: 10 years

Source of referral

Categorised as A\&E/GP referral/Optician referral/Tertiary referral

Time frame: Baseline

Laterality

Categorised as: Right eye/Left eye/Bilateral

Time frame: Baseline

Anatomical diagnosis

Cateogorised as: Acute anterior uveitis / Chronic anterior uveitis / Fuchs heterochromic cyclitis / Intermediate uveitis / Pars planitis / Posterior Uveitis / Panuveitis / Episcleritis / Scleritis

Time frame: Baseline

Aetiological diagnosis

Diagnosed as: Viral / Bacterial / Fungal / Parasitic / Inflammatory / Malignant

Time frame: Baseline

Associated systemic disease

Any associated systemic disease, e.g. HLA-B27 associated disease, Behcet's disease, multiple sclerosis, Vogt-Koyanagi-Harada syndrome, rheumatoid arthritis, collagen vascular disease, tuberculosis, granulomatosis with polyangiitis

Time frame: Baseline

Complications of disease and causes of visual loss at 5 years

Categorised into: Corneal clarity problems / cataract / vitreous debris / retinal detachment / cystoid macular edema / retinal pigment epithelium atrophy / macular scarring / epiretinal membrane / macular hole / steroid response / glaucoma / other optic neuropathy / hypotony \& phthisis / other

Data from ClinicalTrials.gov

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