Assessment of Visual Field-related Endpoints in Patients With Non-arteritic Ischemic Optic Neuropathy

University Hospital Tuebingen16 enrolled

Overview

This present research project intends to collect five quantitative test series: * perimetric examination using static stimuli, assessing the entire (80 degree) visual field with a fast thresholding algorithm (GATE) \[Schiefer 2008\] to know the extent/ magnitude of the visual field defect and its variability within the cohort and over time * D-BCVA, using FrACT \[Bach 2007\] and EDTRS chart \[Ferris 1982\] * RAPD (using swinging flashlight test). * IOP (using applanation tonometer) * RNFT and RNFV using Spectralis OCT (star scan, ring scan 2,8 mm, and volume scan) Optic disk morphology will be documented by fundus photography. This assessment of the above-mentioned data is needed in order to allow for estimation of the spontaneous course / fluctuation of the (quantified) functional and morphometric parameters of the N-AION patients during the follow-up period. This is essential for the estimation of the sample size of the subsequently intended SINN study, that is intended to compare different therapeutic strategies in N-AION patients.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Non-arteritic Ischemic Optic Neuropathy

Interventions

perimetryDEVICE

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: - physical, intellectual and linguistic abilities, in order to understand the test requirements * willingness to comply with the protocol (4 visits) * 41 - 80 years, informed consent * acute N-AION (\< 7 d) * D-BCVA \> 0.1 (2/20) * RAPD ≥ 0.3 logE steps (neutral density filters) and: * spherical ametropia max. ± 8 dpt, cylindrical ametropia max. ± 3 dpt * isocoria, pupil diameter \> 3 mm Exclusion Criteria: * diabetic retinopathy and any other orbital, intracranial or optic nerve disease * history of epilepsy or significant psychiatric disease * medications known to affect visual field sensitivity * infections (e.g. keratitis, conjunctivitis, uveitis) * severe dry eyes * miotic drug * amblyopia * strabismus * any ocular pathology, in either eye, that may interfere with the ability to obtain visual fields, disc imaging or accurate IOP readings * cataract with relevant impairment of vision * keratoconus * intraocular surgery (except for uncomplicated cataract surgery) performed \< 3 month prior to screening * history or signs of any visual pathway affection other than N-AION * history or presence of macular disease and / or macular edema * ocular trauma

Outcomes

Primary Outcomes

Assessment of visual field (VF)-related endpoints in patients with non-arteritic ischemic optic neuropathy (N-AION)

This present research project intends to collect five quantitative test series in order to allow the estimation of the spontaneous course / fluctuation of the (quantified) functional and morphometric parameters of the N-AION patients during the follow-up period. This is essential for the estimation of the sample size of the subsequently intended SINN study, that is intended to compare different therapeutic strategies in N-AION patients

Time frame: 2 years