Safety and Efficacy of Periodontal Surgery in Supra-alveolar-type Defects With or Without Straumann® Emdogain

Inclusion Criteria: * Subjects must have advanced periodontitis: * presence of supra-alveolar-type defects (i.e., defects displaying a predominantly horizontal pattern of bone loss) at a minimum of two adjacent teeth and a maximum of 7 adjacent teeth (FDI positions 17-27 or 37-47) in either the maxilla or the mandible with a PPD of ≥6 mm at a minimum on one site of the examined teeth * Teeth must have \< Class II mobility * Teeth must have horizontal bone loss with an intrabony component of \<2 mm as defined by radiographic evaluation * Subjects must have adequate oral hygiene (full mouth plaque index (PI) of \<25% at baseline (i.e., following initial non-surgical periodontal therapy) * Subjects must have adequate control of inflammation (full mouth bleeding on probing (FMBP) of \<25% at baseline (i.e., following initial non-surgical periodontal therapy) * Subjects must have voluntarily signed the informed consent form before any study related procedures * Subjects must be males and females of at least 18 years of age * Subjects must be committed to the study and the required follow-up visits * Subjects must be in good general health as assessed by the investigator at time of surgery Exclusion Criteria: Pre-surgical exclusion criteria: * Subjects with any contraindications for oral surgical procedures * Subjects with uncontrolled diabetes or other uncontrolled systemic diseases * Subjects with disorders or treatments that compromise wound healing * Subjects with medical conditions requiring chronic high dose steroid therapy * Subjects with bone metabolic diseases * Subjects with radiation or other immuno-oppressive therapy * Subjects with infections or vascular impairment at the surgical site * Subjects who are on antibiotic treatment or chronic anti-inflammatory treatment (≥3 times per week) within 4 weeks prior to surgery. * Subjects with the presence of oral lesions (such as ulceration, malignancy) * Subjects with mucosal diseases (e.g., lichen planus, mouth ulcer) * Subjects with a history of malignant disease in the oral cavity or previous radiotherapy to the head or neck * Subjects with inadequate oral hygiene or unmotivated for adequate home care * Subjects that have been treated with an investigational drug or device within the 30 day period immediately prior to surgery on study day 0. * Subjects who currently smoke * Female subjects who are nursing, pregnant, or plan to become pregnant Secondary exclusion criteria: * Subjects with an osseous defect with an intrabony component of ≥2 mm or involving furcation involvement ≥ class II at the tooth of interest