Neuromuscular Electrical Stimulation (NMES) and Muscle Protein Accretion (ES-PRO)

Maastricht University Medical Center10 enrolled

Overview

In the present study, the effect of a bolus of intrinsically labeled milk directly after one-legged NMES will be studied.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Sarcopenia

Interventions

Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES)DEVICE

One our of one-legged neuromuscular electrical stimulation (NMES)

No Enraf Nonius Tensmed S84 for Neuromuscular electrical stimulation (NMES) NMESDEVICE

No neuromuscular electrical stimulation (NMES) will be applied in the control leg

Eligibility

Sex: MALEMin age: 65 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male * Age 65 - 85 years * 18.5 \< BMI \< 30 kg∙m2 Exclusion Criteria: * Type II diabetes * All co morbidities interacting with mobility and muscle metabolism of the lower limbs (e.g. arthrosis, arthritis, spasticity/rigidity, all neurological disorders, paralysis, hip/knee surgery). * Use of anticoagulants, blood diseases, allergy for lidocaine * Use of NSAIDs and acetylsalicylic acid * Patients suffering from PKU (Phenylketonuria) * Presence of implantable cardioverter defibrillator and/or pacemaker * Performed regular resistance type exercise in the past 6 months

Locations (1)

Maastricht University Medical Centre

Maastricht, Netherlands

Outcomes

Primary Outcomes

Tracer enrichment in the muscle biopsy

Time frame: 4 hours after protein ingestion

Secondary Outcomes

Fractional synthetic rate (FSR)

Time frame: 0-4 hours after protein ingestion

Data from ClinicalTrials.gov

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