Pharmacokinetics of BF2.649 in Renal Impairment

Inclusion Criteria: For subjects with impaired renal function: * Subjects 18 to 75 years old with impaired renal function (MDRD formula between 15 and 89mL/min) medically stable since 3 months * With body mass index (weight/height2) in the range 18 to 32 kg/m2 (inclusive) For healthy subjects: * Healthy subjects 18 to 75 years old with normal renal function (MDRD \> 90 mL/min) and no proteinuria (\<0.15g/L determined by urinalysis) matched with impaired renal function subjects on ethnic group, sex, age (+/- 5 years), and BMI (+/- 20%) Exclusion Criteria: For impaired renal function subjects: * History of hepatic, cardiovascular (including conduction disturbance) or psychiatric disorder or any other condition which, in the opinion of the investigator, would jeopardize the safety of the subject or impact the validity of study results. * Evidence of liver disease * Presence of concomitant pathology requiring intake of any drugs or substances known to be inhibitors or inductors of CYP enzymes * Presence of metabolic or ionic disorders not controlled by adapted treatment * Presence of significant anemia,nephrotic syndrome * Renal transplantation For healthy subjects: * history of renal, cardiovascular, gastrointestinal, hepatic, neurological, endocrine or psychiatric disorders or any surgery which puts them at risk in the opinion of the investigator. * Any treatment within 14 days before inclusion, or within 5 times the elimination half-life of that drug, whichever the longest, including treatment which could lead to inhibition or induction of CYP enzymes - mainly CYP3A4 and CYP2D6 and with the exception of hormonal contraception and menopausal hormone replacement therapy