Continuous Renal Replacement Therapy in the Setting of Orthotopic Liver Transplant

N/AWithdrawnNCT01619449

University of Chicago

Overview

To evaluate the efficacy of continuous renal replacement therapy (CRRT) during orthotopic liver transplantation (OLT) in clearing excess solutes and improving acid-base parameters. The investigators hypothesize that the use of intra-operative CRRT in OLT recipients is associated with increased solute removal and improved acid-base statues when compared to controls who do not receive CRRT

as above

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Conditions

Acute Kidney Injury Liver Disease Chronic Kidney Disease End Stage Kidney Disease

Interventions

Renal replacement therapyPROCEDURE

Liver transplant recipients receiving continuous renal replacement therapy for duration of liver transplant surgery.

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 or older and able to sign consent (or surrogate) * Receiving liver or combined liver-kidney transplant * eGFR \< or equal to 40 ml/min immediately prior to transplant or currently on any form of renal replacement therapy for acute kidney injury or end-stage renal disease * Pre-operative potassium of \< or equal to 5.5 mEq/L Exclusion Criteria: * Pre-operative hemoglobin \< or equal to 7 g/dL * Pre-operative weight \> or equal to 125 kig

Locations (1)

University of Chicago Medicine

Chicago, Illinois, United States

Outcomes

Primary Outcomes

Solute Clearance

To compare the clearance of solutes (ie. potassium, lactate, creatinine and blood urea nitrogen) by CRRT in renally impaired OLT recipients to OLT recipients who do not receive CRRT

Time frame: Intra-operative time

Secondary Outcomes

Renal function and patient outcomes

To compare long-term maintenance of renal function (12 months) and other health outcomes in OLT recipients who received CRRT versus OLT recipients who did not receive OLT

Time frame: 1 year post-operatively

Data from ClinicalTrials.gov

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