This trial is conducted in Japan. The aim of this trial is to assess the safety and tolerability of liraglutide in healthy Japanese male subjects.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
24
5 mcg/kg for 21 days. Injected subcutaneously once daily. Progression to the next dose level based on safety data
5 mcg/kg for 7 days followed by 10 mcg/kg for 14 days. Injected subcutaneously once daily. Progression to the next dose level based on safety data
5 mcg/kg for 7 days followed by 10 mcg/kg for 7 days followed by 15 mcg/kg for 7 days. Injected subcutaneously once daily
Novo Nordisk Investigational Site
Tokyo, Japan
Area under the plasma liraglutide curve
Cmax, maximum plasma liraglutide concentration
tmax, time to reach Cmax
Terminal phase elimination rate-constant
t½, terminal elimination half life
24-hour profiles of serum insulin
24-hour profiles of serum glucose
24-hour profiles of plasma glucagon
Adverse events
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Liraglutide placebo administered to subjects randomised at each dose level in the ratio of 3:1