Trial to Assess Effect of Raltegravir on HTLV-1 Proviral Load

Inclusion Criteria: 1. Documented HTLV-1 infection: documentation may be serologic assay (ELISA, Western blot) and confirmed to be HTLV-1 rather than HTLV-2 by differential Western blot (e.g. Genelabs Diagnostics HTLV Blot 2.4) or PCR. 2. Adequate hematologic function within 14 days before enrollment: ANC \> 1000 cells/mm3, platelet count \> 75,000 cells/mm3. 3. Adequate hepatic function, transaminase \< 3 times the upper limit of normal; bilirubin \< 2.0. 4. Creatinine \< 2.0 5. Karnofsky Performance Status at least 70 6. Age at least 18. 7. Voluntary written informed consent before performance of any study-related procedure not part of normal medical care, with the understanding that consent may be withdrawn by the subject at any time without prejudice to future medical care. 8. Female patients of child bearing potential must have a negative pregnancy test within 72 hrs of initiation of therapy. Female patients are either post-menopausal or surgically sterilized or willing to use two acceptable methods of birth control (i.e., a hormonal contraceptive, intra-uterine device, diaphragm with spermicide, condom with spermicide, or abstinence) during the study. Male patients must agree to use two acceptable methods for contraception for the duration of the study. Women must avoid pregnancy and men avoid fathering children while in the study. 9. Inclusion of Women and Minorities: Both men and women and members of all races and ethnic groups are eligible for this trial. Exclusion Criteria: 1. Acute active infection requiring therapy. Chronic therapy with potentially myelosuppressive agents is allowed provided that entry hematologic criteria are met. 2. Women who are pregnant or breastfeeding. Confirmation that the subject is not pregnant must be established by a negative serum beta-human chorionic gonadotropin (beta-hCG) pregnancy test result obtained during screening. Pregnancy testing is not required for post-menopausal or surgically sterilized women. 3. Patient has received other investigational drugs with 14 days before enrollment 4. Serious medical or psychiatric illness likely to interfere with participation in this clinical study.