A Eye Movement Desensitization Reprocessing (EMDR) Study in Bipolar Traumatized Patients

N/ACompletedNCT01620866

FIDMAG Germanes Hospitalàries20 enrolled

Overview

The purpose of this pilot study is whether Eye Movement Desensitization Reprocessing (EMDR), an approved psychotherapy in posttraumatic stress disorder, improves mood, functioning, quality of life, cognition and BDNF levels in subsyndromal bipolar patients with trauma.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Bipolar Disorder PTSD

Interventions

Eye Movement Desensitization Reprocessing (EMDR)OTHER

EMDR is an effective treatment in PTSD but has never been tested in bipolar traumatized patients.

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Bipolar I or II disorder following DSM-IV criteria * Instable, subsyndromal course defined as at evaluation baseline (HAMD \> 8 \< 15 and/or YMRS \> 7 \< 14) * Good adherence to pharmacological treatment * Major or minor traumatic life-events * EMDR therapists \> 3 years experience * Able to sign informed consent Exclusion Criteria: * Major affective episode in last 3 months * Active drug abuse/dependency * Neurological disease * Suicidal thoughts/ideation * Prior treatment EMDR * DES \> 25

Locations (1)

FIDMAG

Barcelona, Barcelona, Spain

Outcomes

Primary Outcomes

The primary outcome of this study is a statistically significant reduction in the YMRS and/or HDRS in the EMDR group compared with the TAU group.

Patients with subsydromal symptoms, objectified by the YMRS and HDRS, are included in the study. After randomization to EMDR or TAU, group differences in changes in the YMRS and HRDS are measured at visit after intervention (3 months) and at follow-up (6 months). The hypothesize is that the EMDR group will statistically improve in both affective scales when compared to the TAU group.