Bupropion Alone or Combined With Nicotine Gum

University of Wisconsin, Madison608 enrolled

Overview

Focus of this study was to determine if bupropion was more effective for smoking cessation when used alone or combined with nicotine gum.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

608

Conditions

Tobacco Dependence

Interventions

bupropion + nicotine gumDRUG

150 mg bupropion twice daily plus 4 mg nicotine gum as needed (up to 12 pcs/day)

Active bupropion-Placebo gumDRUG

150mg bupropion twice daily plus placebo nicotine gum as needed (up to 12 pcs/day)

Placebo bupropion-Placebo gumDRUG

Placebo bupropion twice daily + placebo nicotine gum as needed (up to 12 pcs/day)

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Smoke 10 or more cigarettes per day * Motivated to quit * No physical or mental health issues that would prevent participation * Not pregnant or willing to prevent pregnancy during treatment Exclusion Criteria: * Carbon monoxide (CO) breath test score below 10 parts per million (ppm) * Center for Epidemiologic Studies Depression Scale (CES-D) score greater than 16 * Heavy alcohol use * History of eating disorder * Suicidality

Locations (1)

UW Center for Tobacco Research and Intervention

Madison, Wisconsin, United States

Outcomes

Primary Outcomes

7-day point prevalence abstinence measured at 6 months

No smoking, not evan a puff, during the 7 days prior to the 6 month follow-up

Time frame: 6 months

Data from ClinicalTrials.gov

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