The investigators examined the efficacy of nefopam in patients undergoing kidney transplantation.
Drug combination are frequently used to relieve postoperative pain. Nefopam can inhibit serotonin, dopamine, and norepinephrine reuptake through central mechanisms. Several studies have demonstrated analgesic efficacy of nefopam in the postoperative period. The purpose of this study is to ascertain the analgesic effect and tolerance of intravenous nefopam in combination with fentanyl based patient-controlled analgesia after kidney transplantation.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
98
Normal saline 200mL : the infusion of 4mL/hr for post-operative 48 hours
Nefopam 160mg (16 mL) mixed to normal saline 184 mL : the infusion of 4mL/hr for post-operative 48 hours
Department of Anesthesiology and Pain Medicine and Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, South Korea
Fentanyl consumption by patient-controlled analgesia
Time frame: 48 hours
Numerical rating score of pain
Time frame: 48 hours
The number of patients who had side effects (e.g. nausea, vomiting, dizziness, headache, confusion, tachycardia)
Time frame: 48 hours
Early postoperative graft function
serum creatinine, estimated glomerular filtration rate, delayed graft function defined as the need for dialysis within 1 week after surgery, acute rejection episodes included both biopsy-proven and clinically suspected acute rejection
Time frame: until discharge
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