The Effect of Topical Application of Tranexamic Acid in Total Hip Arthroplasty Through the Direct Anterior Approach

Universitaire Ziekenhuizen KU Leuven80 enrolled

Overview

The effects of topical application of 3g tranexamic acid for 2 hours prior to opening of the suction drain following a total hip replacement

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

TRIPLE

Enrollment

Conditions

Total Hip Arthroplasty Postoperative Blood Loss

Interventions

Tranexamic AcidDRUG

3g of tranexamic acid is topically applied after THA. The drugs is left for 15 minutes or 2 hours

placeboDRUG

The patients will receive 3g topical TXA for 15 minutes or 2 hours after THA. 33% of the patients will receive 3g of TXA trough a suction drain for 15 minutes after total hip arthroplasty, then the suction drain is opened. 33% will receive the same amount of TXA but the suction drain will only be opened 2 hours after application. The other patients will receive a placebo in the same manner

Eligibility

Sex: ALLMin age: 18 YearsMax age: 99 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients who will receive a unilateral total hip arthroplasty Exclusion Criteria: * coagulopathy * allergy to tranexamic acid * preoperative anemia (a hemoglobin value of \< 11g/dL in females and \< 12g/dL in males) * fibrinolytic disorders * a history of arterial or venous thromboembolic disease * pregnancy * breastfeeding * major comorbidities

Locations (1)

UZ Pellenberg

Pellenberg, Belgium

Outcomes

Primary Outcomes

postoperative blood loss in patients undergoing primary total hip arthroplasty

Time frame: Haemoglobin levels, on which the postopererative blood loss is calculated, is measured preoperative and on day 1 and 4 postoperative

Data from ClinicalTrials.gov

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