The investigators hypothesis is that eating whey protein in the breakfast versus other proteins will results in higher satiety, reduced overall postprandial glycemia and more weight loss in obese diabetic individuals
Recently we have shown that compared to low carbohydrate diet, an isocaloric diet with addition of high calorie and protein breakfast promoted sustained weight loss and prevented weight regain by reducing diet-induced compensatory changes in hunger, cravings and ghrelin suppression. However the effect of isocaloric and isoproteic breakfast with different source of proteins, (whey vs other proteins or vs low protein in breakfast) on weight loss, appetite and on glycemic fluctuations after breakfast lunch and dinner was not explored in obese diabetic individuals. To search whether compared to proteins like tuna, eggs and soy, the intake of whey protein in the breakfast will lead to reduced hunger and overall postprandial glycemia and will enhance weight loss in obese diabetic individuals
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
58
The patients will be assigned to eat 42 g protein namely from Whey protein in the breakfast (660 kcal), lunch (560 kcal) and dinner (280 kcal)
The patients will be assigned to eat 42 g protein from other sources in the breakfast (660 kcal), lunch (560 kcal) and dinner (280 kcal)
The patients will be assigned to eat 22 g protein from other sources in the breakfast (660 kcal), lunch (560 kcal) and dinner (280 kcal)
Daniela Jakubowicz
Holon, N/A = Not Applicable, Israel
Daniela Jakubowicz
Caracas, San Bernardino, Venezuela
Plasma glucose
Postprandial plasma glucose after breakfast, lunch and dinner
Time frame: 12 weeks
Plasma Insulin
Postprandial plasma insulin after breakfast lunch and dinner
Time frame: 12 weeks
Hunger
Postprandial Hunger after breakfast lunch and dinner, assessed with visual analog scale.
Time frame: 12 weeks
Satiety
Postprandial Satiety after breakfast lunch and dinner, assessed with visual analog scale.
Time frame: 12 weeks
Change in body weight
Body weight will be assessed every every two weeks until week 12
Time frame: 12 weeks
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