Studying Genes Associated With Non-Hodgkin Lymphoma in Young Patients

Children's Oncology Group483 enrolled

Overview

This research studies genes associated with non-Hodgkin lymphoma in young patients. Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer

OBJECTIVES: I. To conduct a preliminary investigation of the effects of loci strongly and consistently associated in prior genome-wide association studies (GWAS) and validation studies of childhood/adolescent acute lymphoblastic leukemia (ALL), adult non-Hodgkin lymphoma (NHL), autoimmune diseases, and atopic diseases on the risk of NHL (lymphoblastic and Burkitt lymphomas) in children and adolescents. OUTLINE: DNA samples are analyzed by single nucleotide polymorphism and genotyped by fluorogenic polymerase chain reaction (PCR)-based allelic discrimination (Taqman) assays using the ABI Prism 7900HT reverse transcriptase (RT)-PCR system.

Study Type

OBSERVATIONAL

Enrollment

483

Conditions

Childhood Burkitt Lymphoma Childhood Lymphoblastic Lymphoma

Interventions

laboratory biomarker analysisOTHER

Correlative studies

Eligibility

Sex: ALLMax age: 20 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Slides and/or other available specimens from patients diagnosed with lymphoblastic lymphoma (LL) or Burkitt lymphoma ( BL) enrolled on the Children Oncology Group (COG) protocols 5961, A5971, and ANHL01P1 collected at the time of diagnosis and currently housed at the Biopathology Center at Nationwide Children's Hospital * Samples from non-Hispanic white patients * DNA samples from 384 healthy, anonymous, non-Hispanic white blood donors used as controls * See Disease Characteristics * Not specified

Locations (1)

Children's Oncology Group

Monrovia, California, United States

Outcomes

Primary Outcomes

Potential deviations from Hardy-Weinberg Equilibrium (HWE)

Time frame: Baseline

Data from ClinicalTrials.gov

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