Seal-V Safety and Performance Study

Inclusion Criteria: * Male or female of \>18 years of age * Signed Informed Consent * Patients requiring vascular reconstruction surgeries using synthetic (such as PTFE, Dacron) or autologous (such as native veins) grafts, including the following: * Peripheral bypass surgeries, such as arterio-arterial bypasses \[including: axillo-(bi)femoral, ilio-(bi)femoral, femoro-femoral, ilio-popliteal, femoro-popliteal (including below knee), femoro-tibial vessel bypass\] * Arteriovenous (AV) dialysis access shunt in the upper or lower extremity * Patients able and willing to complete all follow-up visits Exclusion Criteria: * Vascular surgery other than peripheral bypass surgeries and arteriovenous (AV) dialysis access shunt procedures as described above * Reoperation at the same treatment site * Known sensitivity to device materials, such as indigo carmine dye or alginate * Pregnant or lactating women * Systemic infection * Participation in another clinical trial or treatment with any investigational agent in past 30 days * Congenital coagulation disorders (e.g., thrombocytopenia \[\<100,000 platelet count\], thromboasthenia, hemophilia, or von Willebrand disease) * Severe congenital or acquired immunodeficiency (e.g., HIV infection or long term treatment with immunosuppressive drugs) * Prior radiation therapy to the operating field Intraoperative Exclusion Criteria: * Major intraoperative complications that require resuscitation or deviation from the planned surgical procedure * Intraoperative change in planned surgical procedure that results in the patient no longer meeting preoperative inclusion and/or exclusion criteria * Local infection at the operating field