Tobacco Approach Avoidance Training for Adolescent Smokers-1

Yale University40 enrolled

Overview

This is a two part study. Study 1 will compare Approach Avoidance Training (AAT) responses in smokers and nonsmokers in order to confirm that adolescent smokers experience cognitive bias towards tobacco-related stimuli.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Tobacco Use Disorder

Interventions

AAT experimentBEHAVIORAL

Smokers and nonsmokers complete AAT experiment

Eligibility

Sex: ALLMin age: 13 YearsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Between ages 13-18 years * Able to read and write in English. * Smokers: Smoking 5 or more cigarettes daily for at least 6 months; Baseline urine cotinine levels \> 500 ng/ml * Nonsmokers: Never smokers; Baseline urine cotinine levels \< 50 ng/ml Exclusion Criteria: * Current criteria for dependence on another psychoactive substance * Current diagnosis of psychosis, major depression or panic disorder * Regular use of any psychoactive drugs including anxiolytics and antidepressants unless the medication has been taken consistently for 2 months, is currently being monitored by a physician, and the condition for which the medication is taken is considered to be stable * Pregnant or lactating girls, based on self report.

Locations (1)

Yale University, School of Medicine, Dpeartment of Psychiatry

New Haven, Connecticut, United States

Outcomes

Primary Outcomes

automatic approach tendencies towards smoking-related stimuli

For all AAT comparisons, the investigators will compare median scores (to minimize influence of outliers) for cigarette approach and cigarette avoid RTs. The difference between these values gives the smoking AAT-scores, which the investigators expect to not differ from zero in the non-smokers (or to show mild avoidance), while it is expect that smokers will be faster to approach than to avoid cigarettes. ANOVA models will be used to compare scores in smokers vs. nonsmokers. Regression analyses will be used to explore the relationships between impulsivity-related measures and AAT responses.

Time frame: at end of AAT at Day 1

automatic approach tendencies towards smoking-related stimuli

For all AAT comparisons, the investigators will compare median scores (to minimize influence of outliers) for cigarette approach and cigarette avoid RTs. The difference between these values gives the smoking AAT-scores, which the investigators expect to not differ from zero in the non-smokers (or to show mild avoidance), while it is expected that smokers will be faster to approach than to avoid cigarettes. ANOVA models will be used to compare scores in smokers vs. nonsmokers. Regression analyses will be used to explore the relationships between impulsivity-related measures and AAT responses.

Time frame: at end of AAT at Day 8

automatic approach tendencies towards smoking-related stimuli

For all AAT comparisons, the investigators will compare median scores (to minimize influence of outliers) for cigarette approach and cigarette avoid RTs. The difference between these values gives the smoking AAT-scores, which the investigators expect to not differ from zero in the non-smokers (or to show mild avoidance), while it is expected that smokers will be faster to approach than to avoid cigarettes. ANOVA models will be used to compare scores in smokers vs. nonsmokers. Regression analyses will be used to explore the relationships between impulsivity-related measures and AAT responses.

Time frame: at end of AAT at Day 15

automatic approach tendencies towards smoking-related stimuli

Data from ClinicalTrials.gov

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