Studying RNA in Samples From Younger Patients With T-Cell Acute Lymphoblastic Leukemia

Children's Oncology Group20 enrolled

Overview

RATIONALE: Studying samples of blood and tissue from patients with cancer in the laboratory may help doctors identify and learn more about biomarkers related to cancer PURPOSE: This laboratory study is looking into RNA in samples from younger patients with T-cell (T) acute lymphoblastic leukemia (ALL).

OBJECTIVES: * Characterization of the transcriptomic landscape in diagnosis and relapse of T-cell acute lymphoblastic leukemia (ALL) and the direct comparison with corresponding physiological samples (human thymus). * Perform high-throughput transcriptome ribonucleic acid (RNA) sequencing using matched diagnostic T-precursor pediatric ALL samples (peripheral blood or bone marrow). OUTLINE: Archived peripheral blood and bone marrow samples are analyzed for long non-coding RNA (IncRNA) expression and sequencing.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Leukemia

Interventions

RNA analysisGENETIC

proteomic profilingGENETIC

laboratory biomarker analysisOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

DISEASE CHARACTERISTICS: * Peripheral blood and bone marrow samples from pediatric patients with diagnosed and relapsed T-ALL PATIENT CHARACTERISTICS: * Not specified PRIOR CONCURRENT THERAPY: * Not specified

Outcomes

Primary Outcomes

Identification and characterization of IncRNA of pediatric T-cell acute lymphoblastic leukemia

Data from ClinicalTrials.gov

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