The purpose of this study is to the determine the effect of salt intake and Captopril on the ophthalmic artery (OA) blood supply of individuals with Type 2 Diabetes Mellitus.
The overall objective of this study is to ascertain if salt intake affects ophthalmic artery (OA) blood flow. In addition, we will study both the eye and kidney response to ACE inhibition compared to placebo while controlling salt intake in subjects with Type 2 diabetes mellitus. We hypothesize that salt intake will affect OA blood flow. We will initially look at both eye and renal response to subjects on a low salt diet (10mEq Na/day) followed by response to high salt diet (200mEq Na/day). In addition, we may look at eye response while subjects consume their regular diet.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Enrollment
24
Brigham and Women's Hospital
Boston, Massachusetts, United States
RECRUITINGChange in ophthalmic artery blood flow from baseline
Eye blood flow will be measured at baseline and post drug time points (3 total)
Time frame: 1 hour post drug, 2 hours post drug, 3 hours post drug
Change in blood pressure from baseline
Blood pressure will be monitored throughout the study starting at baseline
Time frame: Every 15 minutes for 3 hours
Change in renal plasma flow (RPF) from baseline
Renal Plasma Flow (to measure kidney function) will be measured at baseline and post drug time points (3 total)
Time frame: 1 hour post drug, 2 hours post drug, 3 hours post drug
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