Value of Prothrombin Fragment F1+2 in the Diagnosis of Pulmonary Embolism in Patients With Chronic Obstructive Pulmonary Disease (COPD) Exacerbation

Hillel Yaffe Medical Center20 enrolled

Overview

To access the clinical usefulness of F1+2 in the diagnosis of PE in patients with AECOPD who require hospitalization. Specifically, to determine whether F1+2 may have an additional value in the subgroup of patients with an abnormal D-dimer,to determine whether it may increase the proportion of patients in whom PE can be safely ruled out and to determine the sensitivity, specificity and NPV of F1+2 at various cut-off values.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Chronic Obstructive Pulmonary Disease Pulmonary Embolism

Interventions

CT pulmonary angio, blood testsOTHER

CT pulmonary angiography to determine PE and laboratory blood tests to determine prothrombin fragments F1+2 in blood of COPD patients

Eligibility

Medical Language ↔ Plain English

Inclusion Criteria: * COPD exacerbation * Able to give informed consent * Able to perform spirometry Exclusion Criteria: * Known malignancy * Known hypercoagulable state * Receiving anticoagulant treatment * Pregnancy * Renal failure * Allergy to iodine

Outcomes

Primary Outcomes

Negative Predictive Value of Prothrombin Fragment F1+2

Blood test to determine predictive value of Prothrombin Fragment F1+2 in PE diagnosis in hospitalized COPD patients

Time frame: Six months