Efficacy of Short-term Immunosuppressive Therapy and Anti-allergenic Therapy in Severe Acute Exacerbation of Chronic Hepatitis B

Inclusion Criteria: * serum hepatitis B surface antigen(HBsAg) positive for at least 6 months; * All patients had a poor general condition, manifested as general malaise, fatigue, jaundice and so on; * serum T-Bil of 85.5 mmol/L or more; or serum T-Bil rises 17.1 mmol/L or more per day; or PTA of less than 60%; * serum ALT of 20 times or more the ULN. Exclusion Criteria: * superinfection or co-infection with hepatitis A, C, D, E, cytomegalovirus and HIV, or Epstein-Barr virus; * other liver diseases such as alcoholic liver disease, drug-induced hepatitis, Wilson disease and autoimmune hepatitis; * ascites or gastrointestinal bleeding or peptic ulcer or esophageal varix by electronic gastroscope examination; * decompensated liver cirrhosis; * severe bacterial or fungal infections; * a history of diabetes or cardiac disease or hypertension or nephrosis.